Perioperative atorvastatin in patients >70 years undergoing CABG did not reduce postoperative atrial fibrillation (13.71% vs 14.51%) and was associated with higher in-hospital mortality (8.9% vs 3.7%, p=0.027).
Cohort (n=425)
Absolute Event Rate: 13.71% vs 14.51%
pstrongAimbr //strong To evaluate the effect of perioperative statin treatment on postoperative atrial fibrillation and cardiac mortality in patients undergoing coronary artery bypass grafting.br /strongMethods br //strongA total of 1890 patients who underwent isolated coronary artery bypass were analyzed retrospectively, of which 425br /patients (22.4%) older than 70 were included in the study. The demographic properties, preoperative, operative and postoperative data and other medications of these patients were recorded. Continuous preoperative and postoperative atorvastatin therapy were received by 124 (29.17%) patients; 301 (70.82%) patients were matched to a control group (no-statin group). The two groups were matched by propensity score analysis in terms of atrial fibrillationbr /development and cardiac mortality.br /strongResultsbr //strong Medical history, medical treatment, cardiovascular history, and operative characteristics demonstrated significant heterogeneity in both groups. Postoperative atrial fibrillation was similar in both groups. Before propensity score matching, the percentages of patients in postoperative atrial fibrillation with respect to Atorvastain-group and No-statin-group were 13.71 and 10.3 respectively; however, those were 13.71 and 14.51 after matching. In a multivariate regression analysis, five-vessel bypass (odds ratio OR, 2.354; 95% confidence interval CI, 0.99 to 5.57) was an independent predictor of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting. In-hospital mortalitybr /was higher in the Atorvastatin-group compared with the No-statingroup: 124 (8.9%) versus 301 (3.7%), respectively; p=0.027).br /strongConclusion/strong br /Perioperative atorvastatin treatment is not found to be associated with reduced postoperative atrial fibrillation and cardiac mortality in patients undergoing isolated coronary artery bypass grafting above the age of seventy years/p
Kunt et al. (Sat,) conducted a cohort in coronary artery bypass grafting (n=425). Perioperative atorvastatin vs. No statin was evaluated on postoperative atrial fibrillation. Perioperative atorvastatin in patients >70 years undergoing CABG did not reduce postoperative atrial fibrillation (13.71% vs 14.51%) and was associated with higher in-hospital mortality (8.9% vs 3.7%, p=0.027).
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