Discovery of Cellular Regulation by Protein Degradation

was born and educated in Russia and was 30 at the time of emigration to the United States, in 1977. Over the last three decades, studies by my laboratory encompassed several fields. Although the title of this article is about our main contribution to date, I describe other significant advances as well, in addition to new biochemical and genetic methods introduced by the lab. A condensed summary, below, is followed by an account of specific discoveries and inventions in their historical contexts.