Why the study?
Does retrograde coronary perfusion with selective brain cooling improve myocardial metabolism and reduce ventricular fibrillation compared to direct coronary artery perfusion in dogs?
Does retrograde coronary perfusion with selective brain cooling improve myocardial metabolism and reduce ventricular fibrillation compared to direct coronary artery perfusion in dogs?
Both retrograde and direct coronary perfusion with selective brain cooling in hypothermic dogs resulted in a high incidence of ventricular fibrillation, suggesting that operation at normal temperature using extracorporeal circulation is preferable.
Answers are grounded in this paper and cite their sources.
High VF incidence with both perfusion methods in hypothermic dogs; leaves open whether normothermic extracorporeal circulation is preferable, pending clinical data.
Retrograde coronary perfusion in combination with selective brain cooling by irrigation was investigated in dogs, in comparison with direct coronary artery perfusion. 2. High incidence of ventricular fibrillation was seen in both methods in hypothermic state. Operation at the normal temperature using extracorporeal circulation is desirable, 3. In view of the above results optimal perfusion pressure appears 30 mm Hg. in retroperfusion, while 100 mm Hg. in direct coronary artery perfusion. 4. The right ventricle anoxia is an undesirable feature in retroperfusion, while the left ventricle showed a tendency to slight anoxia in both methods.
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Naomi Hayashi (1959) studied this question.
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