Why the study?
Does profound hypothermic circulatory arrest with continuous retrograde cerebral perfusion protect the brain during thoracic aortic surgery through a left thoracotomy?
Observational (n=18)
Does profound hypothermic circulatory arrest with continuous retrograde cerebral perfusion protect the brain during thoracic aortic surgery through a left thoracotomy?
The combination of profound hypothermic circulatory arrest and continuous retrograde cerebral perfusion provides adequate brain protection during aortic surgery involving the distal arch through a left thoracotomy.
May support cerebral protection in left thoracotomy distal arch repair; hypothesis-generating and should not yet change practice.
The authors used profound hypothermic circulatory arrest and continuous retrograde cerebral perfusion for aortic surgery that involved the distal arch through a left thoracotomy. For the first seven patients, oxygenated blood from cardiopulmonary bypass was perfused retrogradely through a venous cannula positioned into the right atrium. In the last 11 cases, venous blood, provided by a perfusion from the lower body, was circulated passively in the brain with the descending aorta clamped. The period of profound hypothermic circulatory arrest was 34.6 ± 11.1 min, and continuous retrograde cerebral perfusion was 31.3 ± 11.1 min. Seventeen patients survived, but there was one early death. Two patients with a severely atherosclerotic aneurysm developed permanent neurological dysfunction. The combination of profound hypothermic circulatory arrest, continuous retrograde cerebral perfusion and open aortic anastomosis through a left thoracotomy protects the brain adequately, and facilitates evacuation of debris and air in the aortic arch. It produces satisfactory results for aortic surgery that involves the distal arch.
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Ogino et al. (2000) conducted an observational in Aortic surgery involving the distal arch (n=18). Profound hypothermic circulatory arrest and continuous retrograde cerebral perfusion was evaluated.
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