What question did this study set out to answer?

To determine whether the Th17 and interleukin-23 cytokine system is up-regulated in the salivary glands, saliva, and sera of mice and patients with primary Sjögren's syndrome.

February 29, 2008Arthritis & RheumatismOpen Access

Salivary gland tissue expression of interleukin‐23 and interleukin‐17 in Sjögren's syndrome: Findings in humans and mice

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To determine whether the Th17 and interleukin-23 cytokine system is up-regulated in the salivary glands, saliva, and sera of mice and patients with primary Sjögren's syndrome.
Evaluated sera, saliva, and salivary gland tissue from C57BL/6.NOD-Aec1Aec2 mice and human patients diagnosed with primary Sjögren's syndrome.
Analyzed IL-17 and IL-23 expression across specimens using immunohistochemistry, real-time polymerase chain reaction, and Luminex multiplex assays.
Immunohistochemical analysis demonstrated strong positive staining for IL-17 and IL-23 in lymphocytic foci and diffuse staining in epithelial tissues in both mice and patients.
Salivary gland expression of IL-17 and IL-23 in mice correlated over time with expression of retinoic acid-related orphan receptor gammat, the master transcription factor for Th17 cells.
IL-17 was present in mouse sera up to 16 weeks of age, while variable levels of both IL-17 and IL-6 were detected across patient sera and saliva.

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Implication

Translational study reveals elevated interleukin-23 and interleukin-17 in human and murine Sjögren's syndrome, indicating Th17 pathway involvement in salivary gland inflammation.

Cite This Study

Nguyen et al. (2008) studied this question.

synapsesocial.com/papers/6a7f138b5d931e56330fc01f https://doi.org/10.1002/art.23214

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Implication

Translational study reveals elevated interleukin-23 and interleukin-17 in human and murine Sjögren's syndrome, indicating Th17 pathway involvement in salivary gland inflammation.

Salivary gland tissue expression of interleukin‐23 and interleukin‐17 in Sjögren's syndrome: Findings in humans and mice

Key Points

Discussion

Implication

Cite This Study

Salivary gland tissue expression of interleukin‐23 and interleukin‐17 in Sjögren's syndrome: Findings in humans and mice

Key Points

Discussion

Implication

Cite This Study

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