Key result
Anthracycline exposure in children with malignancies resulted in cardiac dysfunction in 14% within a month and 25% within a year.
Why the study?
Does anthracycline chemotherapy cause acute and early-onset chronic progressive cardiotoxicity in children with malignancies?
Population
110 children with childhood malignancies, mean age 74±44 months, 68.2% male, at a tertiary care centre in…
Design
Cohort
Follow-up
1 year
Authors
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Warrants close echocardiographic monitoring in pediatric anthracycline recipients; leaves open causality and optimal surveillance strategies pending higher-level evidence.
Cohort (n=110)
No
Does anthracycline chemotherapy cause acute and early-onset chronic progressive cardiotoxicity in children with malignancies?
Anthracycline chemotherapy in children with malignancies is associated with a high incidence of acute and early-onset cardiotoxicity, emphasizing the need for close echocardiographic monitoring.
Saleem et al. (2013) conducted a cohort in Childhood malignancies (n=110). Anthracycline (doxorubicin and/or daunorubicin) was evaluated on Cardiac dysfunction within 1 year. Anthracycline exposure in children with malignancies resulted in cardiac dysfunction in 14% within a month and 25% within a year.
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