Key result
Active COVID-19 infection in patients with STEMI was significantly associated with higher in-hospital mortality for both out-of-hospital (15.2% vs 11.2%) and in-hospital (78.5% vs 46.1%) presentations.
Why the study?
There has been limited research on patients presenting with ST-segment elevation myocardial infarction and concomitant COVID-19 infection.
Does active COVID-19 infection increase in-hospital mortality in patients hospitalized with STEMI?
Cohort (n=80,449)
Yes
Does active COVID-19 infection increase in-hospital mortality in patients hospitalized with STEMI?
Effect estimate: Absolute difference 4.1% (95% CI 1.1%-7.0%)
Absolute Event Rate: 15.2% vs 11.2%
p-value: p=0.007
Concomitant COVID-19 infection in patients with STEMI is associated with significantly higher in-hospital mortality compared to STEMI patients without COVID-19.
May warrant heightened caution for in-hospital STEMI with active COVID-19; leaves open causality and should not yet change practice.
IMPORTANCE: There has been limited research on patients with ST-segment elevation myocardial infarction (STEMI) and COVID-19. OBJECTIVE: To compare characteristics, treatment, and outcomes of patients with STEMI with vs without COVID-19 infection. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study of consecutive adult patients admitted between January 2019 and December 2020 (end of follow-up in January 2021) with out-of-hospital or in-hospital STEMI at 509 US centers in the Vizient Clinical Database (N = 80 449). EXPOSURES: Active COVID-19 infection present during the same encounter. MAIN OUTCOMES AND MEASURES: The primary outcome was in-hospital mortality. Patients were propensity matched on the likelihood of COVID-19 diagnosis. In the main analysis, patients with COVID-19 were compared with those without COVID-19 during the previous calendar year. RESULTS: The out-of-hospital STEMI group included 76 434 patients (551 with COVID-19 vs 2755 without COVID-19 after matching) from 370 centers (64.1% aged 51-74 years; 70.3% men). The in-hospital STEMI group included 4015 patients (252 with COVID-19 vs 756 without COVID-19 after matching) from 353 centers (58.3% aged 51-74 years; 60.7% men). In patients with out-of-hospital STEMI, there was no significant difference in the likelihood of undergoing primary percutaneous coronary intervention by COVID-19 status; patients with in-hospital STEMI and COVID-19 were significantly less likely to undergo invasive diagnostic or therapeutic coronary procedures than those without COVID-19. Among patients with out-of-hospital STEMI and COVID-19 vs out-of-hospital STEMI without COVID-19, the rates of in-hospital mortality were 15.2% vs 11.2% (absolute difference, 4.1% [95% CI, 1.1%-7.0%]; P = .007). Among patients with in-hospital STEMI and COVID-19 vs in-hospital STEMI without COVID-19, the rates of in-hospital mortality were 78.5% vs 46.1% (absolute difference, 32.4% [95% CI, 29.0%-35.9%]; P < .001). CONCLUSIONS AND RELEVANCE: Among patients with out-of-hospital or in-hospital STEMI, a concomitant diagnosis of COVID-19 was significantly associated with higher rates of in-hospital mortality compared with patients without a diagnosis of COVID-19 from the past year. Further research is required to understand the potential mechanisms underlying this association.
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Saad et al. (2021) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=80,449). Active COVID-19 infection vs. Patients without COVID-19 during the previous calendar year was evaluated on in-hospital mortality (Absolute difference 4.1%, 95% CI 1.1%-7.0%, p=0.007). Active COVID-19 infection in patients with STEMI was significantly associated with higher in-hospital mortality for both out-of-hospital (15.2% vs 11.2%) and in-hospital (78.5% vs 46.1%) presentations.
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