Why the study?
Does staurosporine induce apoptosis in pulmonary artery smooth muscle cells via activation of KV channels and mitochondrial membrane depolarization?
Population
Pulmonary artery smooth muscle cells (PASMCs)
Comparison
Staurosporine treatment, high K+, and… vs Untreated/control cells (implied)
Design
Preclinical
Authors
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Hypothesis-generating for KV channel modulation in pulmonary vascular remodeling; human studies required before any clinical consideration.
Does staurosporine induce apoptosis in pulmonary artery smooth muscle cells via activation of KV channels and mitochondrial membrane depolarization?
Staurosporine-induced apoptosis in pulmonary artery smooth muscle cells is mediated by activation of plasmalemmal KV channels and mitochondrial membrane depolarization.
Krick et al. (2001) studied this question.
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