This review highlights the endocrine role of white adipose tissue and how its dysfunction and inflammatory molecule production contribute to insulin resistance and cardiovascular risk in obesity.
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Adipose inflammation may inform cardiometabolic risk assessment in obesity; leaves open whether targeted interventions improve outcomes in trials.
White adipose tissue (WAT) is considered an endocrine organ. When present in excess, WAT can influence metabolism via biologically active molecules. Following unregulated production of such molecules, adipose tissue dysfunction results, contributing to complications associated with obesity. Previous studies have implicated pro- and anti-inflammatory substances in the regulation of inflammatory response and in the development of insulin resistance. In obese individuals, pro-inflammatory molecules produced by adipose tissue contribute to the development of insulin resistance and increased risk of cardiovascular disease. On the other hand, the molecules with anti-inflammatory action, that have been associated with the improvement of insulin sensitivity, have your decreased production. Imbalance of these substances contributes significantly to metabolic disorders found in obese individuals. The current review aims to provide updated information regarding the activity of biomolecules produced by WAT.
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Martins et al. (2014) studied this question.
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