Key result
Inactive patients with non-NPSLE exhibited abnormal low-frequency oscillations in multiple brain regions compared to healthy controls, suggesting potential imaging biomarkers of brain dysfunction.
Why the study?
The study was conducted to investigate the characteristics of spontaneous brain activity in inactive patients with nonneuropsychiatric systemic lupus erythematosus.
Cross-Sectional (n=51)
Inactive patients with non-NPSLE exhibit abnormal low-frequency oscillations in multiple brain regions, suggesting potential imaging biomarkers for brain dysfunction.
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Should not yet change imaging or management of inactive non-NPSLE; leaves open whether these oscillations are valid biomarkers of brain dysfunction.
Chen et al. (2019) conducted a cross-sectional in Nonneuropsychiatric systemic lupus erythematosus (non-NPSLE) (n=51). Inactive non-NPSLE vs. Healthy controls was evaluated on Spontaneous brain activity evaluated by ALFF, fALFF, and PerAF. Inactive patients with non-NPSLE exhibited abnormal low-frequency oscillations in multiple brain regions compared to healthy controls, suggesting potential imaging biomarkers of brain dysfunction.
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