Inappropriate Secretion of Antidiuretic Hormone after Transsphenoidal Surgery for Pituitary Tumors

THE syndrome of inappropriate secretion of antidiuretic hormone (ADH) has been noted in association with a variety of neurologic disorders,1 2 3 but its occurrence as a transient complication of pituitary surgery performed by the transsphenoidal approach has been incompletely defined and poorly recognized.2 In our patients, the onset of this syndrome was delayed until the second week after the surgical procedure, so that its manifestations usually occurred after the patient had been sent home for convalescence. This temporal factor, in conjunction with the often nonspecific character of the clinical presentation of the syndrome, indicates a need for careful awareness of such . . .