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March 23, 2004HypertensionOpen Access

Angiotensin II Type-1 Receptor Blocker Valsartan Enhances Insulin Sensitivity in Skeletal Muscles of Diabetic Mice

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Why the study?

Does valsartan improve insulin-mediated glucose uptake in type 2 diabetic KK-Ay mice?

Population

Type 2 diabetic KK-Ay mice and AT2 receptor null mice

Design

Preclinical

Authors

TSTetsuya ShiuchiShikoku UniversityMIMasaru IwaiKumamoto UniversityHLHuan-Sheng LiEhime University

Discussion

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Implication

Preclinical data in diabetic mice indicate BP-independent insulin sensitization; leaves open clinical relevance in human type 2 diabetes.

Structured PICO

Does valsartan improve insulin-mediated glucose uptake in type 2 diabetic KK-Ay mice?

P
Population
Type 2 diabetic KK-Ay mice and AT2 receptor null mice
I
Intervention
Valsartan at a dose of 1 mg/kg per day
O
Outcome
Insulin-mediated 2-[3H]deoxy-d-glucose (2-[3H]DG) uptake into skeletal musclesurrogate

Valsartan enhances insulin sensitivity and glucose uptake in skeletal muscle of diabetic mice by stimulating the insulin signaling cascade and enhancing GLUT4 translocation, independent of blood pressure lowering.

Cite This Study

Shiuchi et al. (2004) studied this question.

synapsesocial.com/papers/6a7f1e640d396ca0cf0fc87fhttps://doi.org/10.1161/01.hyp.0000125142.41703.64
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