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October 12, 2022Frontiers in MedicineOpen Access

The severity of depression is associated with pelvic inflammatory diseases: A cross-sectional study of the United States National Health and Nutrition Examinations from 2013 to 2018

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Key result

Higher depression severity was significantly associated with an increased prevalence of pelvic inflammatory disease, with a 10% increased risk per 1-point increase in depression score (OR 1.10).

Why the study?

Depression in patients with pelvic inflammatory disease has received increasing attention, but the relationship between depression severity and risk factors for the condition remains to be investigated.

Does depression severity increase the prevalence of pelvic inflammatory disease in US females?

Population

Females participating in NHANES from 2013 to 2018

Comparison

Different levels of depression severity

Design

Cross-sectional study

Authors

THTianJiao HuangShandong University of Traditional Chinese MedicineRCRen-Shuang CaoChinese Academy of Medical Sciences & Peking Union Medical CollegePLPengfei LiuTianjin University of Traditional Chinese Medicine

Discussion

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Implication

Hypothesis-generating for depression assessment in PID; leaves open causality and any role for treatment in gynecologic outcomes.

Study Design

Type

Cross-Sectional (n=5,432)

Structured PICO

Does depression severity increase the prevalence of pelvic inflammatory disease in US females?

P
Population
5,432 female participants aged 12 years and older from the US NHANES 2013-2018 database were evaluated for the association between depression severity and pelvic inflammatory disease.
E
Exposure
Depression severity (assessed by PHQ-9 score)
C
Comparator
No depression or lower severity of depression
O
Outcome
Prevalence of pelvic inflammatory disease (PID) assessed based on the NHANES Reproductive Health Questionnaire

Main Result

Odds Ratio: 1.1 (95% CI 1.08–1.12)

p-value: p=<0.0001

Depression severity is positively associated with the prevalence of pelvic inflammatory disease in US females, suggesting that depression should be actively assessed and managed in patients with PID.

Limitations

  • Cross-sectional design cannot establish causality.
  • Study population is limited to women in the USA.
  • Lack of serum C-reactive protein (CRP) data.
  • Limited information regarding the treatment, prognosis, and duration of specific PID.
  • Potential residual confounding due to unmeasurable covariates.
  • Cross-sectional analysis can only examine the distribution of risk factors at a specific time
  • Study population is limited to adult women in the USA
  • Lack of serum C-reactive protein (CRP) data
  • Limited information regarding the treatment, prognosis, and duration of specific PID
  • Residual confusion in unmeasurable covariates due to secondary nature of analysis

Cite This Study

Huang et al. (2022) conducted a cross-sectional in Pelvic inflammatory disease (n=5,432). Depression severity vs. No depression / Lower depression scores was evaluated on Prevalence of pelvic inflammatory disease (OR 1.10, 95% CI 1.08-1.12, p=<0.0001). Higher depression severity was significantly associated with an increased prevalence of pelvic inflammatory disease, with a 10% increased risk per 1-point increase in depression score (OR 1.10).

synapsesocial.com/papers/6a7f237ce9877cc9856a7a41https://doi.org/10.3389/fmed.2022.926351
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Also Consider

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