Key result
The dynamic equilibrium between the disordered relaxed and super-relaxed states of myosin regulates striated muscle contraction and is altered by hypertrophic cardiomyopathy mutations and therapeutics.
Why the study?
The discovery of a functional super-relaxed (SRX) state of myosin in dynamic equilibrium with the disordered relaxed (DRX) state prompted an examination of how modulating this equilibrium regulates striated muscle contraction.
The dynamic equilibrium between the disordered relaxed (DRX) and super-relaxed (SRX) states of myosin is a key regulatory mechanism of striated muscle contraction, with implications for understanding and treating hypertrophic cardiomyopathy.
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Should not yet change HCM practice; leaves open whether targeting the DRX–SRX equilibrium will improve clinical outcomes.
A 2021 study conducted a review in Hypertrophic cardiomyopathy. The dynamic equilibrium between the disordered relaxed and super-relaxed states of myosin regulates striated muscle contraction and is altered by hypertrophic cardiomyopathy mutations and therapeutics.
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