What question did this study set out to answer?

To evaluate the clinical efficacy of probiotics compared with controls in the management of acne vulgaris.

May 19, 2026Journal of Cutaneous Medicine and SurgeryOpen Access

Role of Probiotics in Managing Acne Vulgaris: A Systematic Review and Meta-Analysis of Clinical Trials

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Authors

NJNarachai JulanonKhon Kaen University CUChanita UnhapipatpongKhon Kaen University RWRachot WongjirattikarnKhon Kaen University

Discussion

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Implication

Systematic review and meta-analysis reveals oral probiotics reduce overall acne severity without significantly lowering lesion counts, indicating potential benefits in mild-to-moderate disease.

Key Points

To evaluate the clinical efficacy of probiotics compared with controls in the management of acne vulgaris.
Searched 3 electronic databases through June 30, 2024, to identify clinical trials evaluating probiotics versus controls in acne across 13 studies (18 study arms, N=1,453).
Evaluated primary outcomes of standardized mean differences (SMDs) for changes in total lesion count (TLC), noninflammatory lesion count (NILC), and inflammatory lesion count (ILC), alongside secondary measures including Global Acne Grading System (GAGS) scores.
Probiotics demonstrated no significant reduction compared with controls in TLC (SMD, -0.22; 95% CI: -0.50 to 0.07; I² = 75%), NILC (SMD, -0.20; 95% CI: -0.48 to 0.08; I² = 72%), or ILC (SMD, -0.13; 95% CI: -0.34 to 0.09; I² = 52%).
Oral probiotics significantly reduced overall acne severity on the GAGS scale versus controls (SMD, -0.47; 95% CI: -0.81 to -0.13; I² = 67%), with maximal benefits observed in mild-to-moderate acne treated with multi-strain Lactobacillus combinations for at least 12 weeks.

Cite This Study

Julanon et al. (2026) studied this question.

synapsesocial.com/papers/6a7f2ee3b1a7ff7f700dfcc7 https://doi.org/10.1177/12034754261445880

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Implication

Systematic review and meta-analysis reveals oral probiotics reduce overall acne severity without significantly lowering lesion counts, indicating potential benefits in mild-to-moderate disease.

Role of Probiotics in Managing Acne Vulgaris: A Systematic Review and Meta-Analysis of Clinical Trials

Discussion

Member takes

Implication

Key Points

Cite This Study

Role of Probiotics in Managing Acne Vulgaris: A Systematic Review and Meta-Analysis of Clinical Trials

Discussion

Member takes

Implication

Key Points

Cite This Study

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