Key result
Overweight individuals with a resting heart rate ≥80 bpm had a significantly higher risk of developing diabetes (OR 4.61) compared to normal-weight individuals with a heart rate <80 bpm.
Why the study?
Does the combination of overweight and resting heart rate ≥80 bpm increase the incidence of prediabetes and diabetes in Inner Mongolian adults?
Cohort (n=1,729)
Yes
Does the combination of overweight and resting heart rate ≥80 bpm increase the incidence of prediabetes and diabetes in Inner Mongolian adults?
Odds Ratio: 4.61 (95% CI 2.47–8.61)
Absolute Event Rate: 19.5% vs 6%
p-value: p=<0.001
The coexistence of overweight and a resting heart rate ≥80 bpm significantly amplifies the risk of developing prediabetes and diabetes, highlighting the importance of weight management in individuals with higher resting heart rates.
May inform risk stratification for diabetes prevention in overweight adults; hypothesis-generating in observational cohorts.
We aimed to investigate the cumulative effect of overweight and resting heart rate on prediabetes/diabetes incidence in an 10-year follow-up study in Inner Mongolians. Among 1729 participants who were free from prediabetes and diabetes at baseline, 503 and 155 subjects developed prediabetes and diabetes, respectively. We categorized the participants into 4 subgroups according to overweight and resting heart rate status. The multivariate-adjusted OR (95% CI) in normal weight with heart rate ≥80 bpm, overweight with heart rate <80 bpm, and overweight with heart rate ≥80 bpm were 1.24 (0.95-1.61), 1.83 (1.29-2.61), 2.20 (1.41-3.45) for prediabetes and 1.52 (0.97-2.40), 3.64 (2.21-6.01), 4.61 (2.47-8.61) for diabetes, respectively, compared with normal weight with heart rate <80 bpm. The area under ROC curve (AUC) for the prediction of diabetes incidence for a model containing overweight and resting heart rate, along with conventional factors (AUC = 0.751), was significantly (P = 0.003) larger than the one containing only conventional factors (AUC = 0.707). Our study indicated that overweight was an independent risk factor of prediabetes and diabetes, and overweight with faster resting heart rate might further increase the risk of prediabetes and diabetes.
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Zhang et al. (2016) conducted a cohort in Prediabetes and diabetes (n=1,729). Overweight and resting heart rate ≥80 bpm vs. Normal weight and resting heart rate <80 bpm was evaluated on Incidence of diabetes (OR 4.61, 95% CI 2.47-8.61, p=<0.001). Overweight individuals with a resting heart rate ≥80 bpm had a significantly higher risk of developing diabetes (OR 4.61) compared to normal-weight individuals with a heart rate <80 bpm.
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