Key result
Elevated serum high-sensitivity C-reactive protein levels (highest vs. lowest quartile) significantly increased the risk of developing atrial fibrillation by 89% (HR 1.89) in a general Japanese population.
Why the study?
Serum hs-CRP is a known risk factor for developing AF in Western countries, but few community-based studies have investigated this association in general Asian populations.
Does elevated serum hs-CRP increase the risk of developing atrial fibrillation in a general Japanese population?
Cohort (n=2,510)
No
Does elevated serum hs-CRP increase the risk of developing atrial fibrillation in a general Japanese population?
Elevated serum hs-CRP levels are an independent risk factor for the development of atrial fibrillation in a general Japanese population, suggesting systemic inflammation plays a role in AF pathogenesis across different ethnicities.
Answers are grounded in this paper and cite their sources.
hs-CRP elevation may flag higher AF risk in Japanese adults; extends Western data but remains hypothesis-generating and should not change practice.
BACKGROUND: Atrial fibrillation (AF) is a common arrhythmia in the elderly, and causes complications such as cardioembolic stroke. Serum high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, has been reported to be a risk factor for developing AF in Western countries. However, few community-based studies have examined this issue in general Asian populations. METHODS AND RESULTS: A total of 2,510 community-dwelling Japanese participants aged ≥40 years without a history of AF were divided into 4 groups according to the sex-specific quartiles of serum hs-CRP concentrations (Q1, lowest and Q4, highest) and followed up for 24 years. The hazard ratios and their 95% confidence intervals for the development of AF were estimated using a Cox proportional hazards model. During the follow up, 234 subjects developed AF. The risk of AF increased significantly with elevating serum hs-CRP levels after adjustment for potential confounding factors (hazard ratio [95% confidence interval], Q1, 1.00 [reference]; Q2, 1.26 [0.83-1.92]; Q3, 1.77 [1.18-2.66]; and Q4, 1.89 [1.24-2.86]; P for trend <0.001). CONCLUSIONS: The study findings suggest that elevated serum hs-CRP levels are an independent risk factor for the development of AF in a general Japanese population.
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A 2021 study conducted a cohort in Atrial fibrillation (n=2,510). Elevated serum high-sensitivity C-reactive protein (hs-CRP) levels vs. Lowest quartile of serum hs-CRP levels was evaluated on Development of atrial fibrillation (HR 1.89, 95% CI 1.24-2.86, p=0.003). Elevated serum high-sensitivity C-reactive protein levels (highest vs. lowest quartile) significantly increased the risk of developing atrial fibrillation by 89% (HR 1.89) in a general Japanese population.
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