Why the study?
What are the acute cardiovascular changes following induction of anaesthesia with disoprofol in heavily premedicated patients with coronary artery disease?
What are the acute cardiovascular changes following induction of anaesthesia with disoprofol in heavily premedicated patients with coronary artery disease?
Induction of anaesthesia with disoprofol 2 mg/kg in patients with coronary artery disease causes acute hemodynamic changes, including decreased blood pressure and stroke volume with compensatory tachycardia, similar to other intravenous induction agents.
Alerts clinicians to monitor hemodynamics during disoprofol induction in CAD; leaves open comparative effects versus other agents in prospective studies.
Summary The acute cardiovascular changes following induction of anaesthesia with disoprofol 2 mg/kg have been studied in eight heavily premedicated patients with coronary artery disease. There was a significant increase in heart rate (+ 19%) and significant falls in mean arterial blood pressure (− 23%), peripheral vascular resistance (− 19%) and stroke volume (− 26%). Cardiac output did not change significantly. The extent and pattern of these changes are very similar to those seen after other intravenous induction agents.
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AL‐KHUDHAIRI et al. (1982) studied this question.
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