Key result
Prolonged sitting resulted in a significant decrease in lower-limb flow-mediated dilation at 120 minutes (SMC -0.85; 95% CI -1.32 to -0.38) and 180 minutes (SMC -1.18; 95% CI -1.69 to -0.66).
Why the study?
The dose-response relationship between prolonged sitting and vascular function in healthy individuals and those with metabolic disturbances, as well as the acute effects of interrupting prolonged sitting, remained to be determined.
Does prolonged uninterrupted sitting acutely impair vascular function in healthy individuals and those with metabolic disturbances?
Population
Healthy individuals and those with metabolic disturbances in randomized crossover, quasi-randomized, and parallel group trials
Comparison
Prolonged sitting vs pre-sitting baseline or interrupted sitting
Design
Systematic review and meta-analysis
Authors
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Caution against uninterrupted sitting beyond 2 hours; confirms acute endothelial impairment and extends sedentary behavior evidence.
Meta-Analysis
Does prolonged uninterrupted sitting acutely impair vascular function in healthy individuals and those with metabolic disturbances?
Standardized Mean Difference: -0.85 (95% CI -1.32–-0.38)
Prolonged uninterrupted sitting acutely impairs lower-limb vascular function in healthy adults, highlighting the potential cardiovascular risks of sedentary behavior.
Taylor et al. (2022) conducted a meta-analysis in Healthy individuals and those with metabolic disturbances. Prolonged sitting vs. Active interruptions or baseline was evaluated on Lower-limb flow-mediated dilation (FMD) at 120 minutes (SMC -0.85, 95% CI -1.32 to -0.38). Prolonged sitting resulted in a significant decrease in lower-limb flow-mediated dilation at 120 minutes (SMC -0.85; 95% CI -1.32 to -0.38) and 180 minutes (SMC -1.18; 95% CI -1.69 to -0.66).
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