Population
In vitro biochemical model using smooth muscle myosin, actin, and caldesmon
Comparison
Addition of caldesmon vs Absence of caldesmon; presence vs absence of…
Design
Preclinical
Authors
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Supports caldesmon as modulator of actin-myosin interaction; leaves open physiologic effects on smooth muscle contractility in vivo.
This basic science study demonstrates that caldesmon binds to smooth muscle myosin and can cross-link actin and myosin, providing insight into smooth muscle contractile regulation.
Ikebe et al. (1988) studied this question.
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