Key result
Preterm birth significantly increased the risk of hospital admission for RSV bronchiolitis compared to term birth (RR 1.9), alongside other conditions like Down's syndrome and cerebral palsy.
Population
296,618 infants born in 71 English NHS hospitals between April 1, 2007, and March 31, 2008, followed up to…
Design
Cohort
Follow-up
up to 1 year of age
Authors
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May inform RSV prophylaxis targeting in preterm infants; leaves open impact on overall burden given most admissions in term births.
Cohort (n=296,618)
Yes
Relative Risk: 1.9 (95% CI 1.8–2)
Absolute Event Rate: 47.3% vs 22.4%
Most infants admitted for RSV bronchiolitis are born at term without known risk factors, though the relative risk is significantly higher for those born preterm or with conditions like Down's syndrome and cerebral palsy.
Murray et al. (2014) conducted a cohort in RSV bronchiolitis (n=296,618). Preterm birth vs. Term birth was evaluated on Hospital admission with a diagnosis of bronchiolitis (RR 1.9, 95% CI 1.8-2.0). Preterm birth significantly increased the risk of hospital admission for RSV bronchiolitis compared to term birth (RR 1.9), alongside other conditions like Down's syndrome and cerebral palsy.
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