January 1, 1993Archives of Physiology and Biochemistry
An experimental model of hypoxia on isolated rat heart in recirculating system: study of fatty acid metabolism with an iodinated fatty acid
Population
Isolated rat hearts
Comparison
Hypoxia perfusion for 40 min with oleate… vs Normoxia (pO2 = 660 mmHg) perfusion
Design
Preclinical
Follow-up
40 min
Authors
Discussion
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Implication
Hypoxic metabolic shifts in rat hearts should not guide clinical decisions; leaves open IHA utility for human ischemia imaging.
Structured PICO
P
Population
Isolated rat hearts
I
Intervention
Hypoxia (pO2 = 220 mmHg) perfusion for 40 min with oleate, glucose, lactate, pyruvate and iodohexadecenoic acid (IHA)
C
Comparator
Normoxia (pO2 = 660 mmHg) perfusion
O
Outcome
Fatty acid metabolism (IHA uptake, intracellular fate, beta oxidation) and cardiac performancesurrogate
Lipid metabolism in hypoxic isolated rat hearts can be effectively explored by external detection using the iodinated fatty acid IHA.
Cite This Study
Poizat et al. (1993) studied this question.