Why the study?
Does the presence of glucose improve the recovery of contraction strength in cat papillary muscles subjected to anoxia?
Does the presence of glucose improve the recovery of contraction strength in cat papillary muscles subjected to anoxia?
The presence of glucose during prolonged anoxia is critical for the subsequent aerobic recovery of myocardial contractile function in a preclinical model.
Answers are grounded in this paper and cite their sources.
May inform substrate use in experimental anoxia models; leaves open clinical translation to myocardial ischemia.
Papillary muscles from the right ventricle of the cat were subjected to periods of anoxia ranging from 15–60 minutes with and without glucose in the Krebs-Henseleit (bicarbonate) solution. Under aerobic conditions glucose was not required in the medium for the maintenance of contraction strength. Under anaerobic conditions the contraction strength decreased rapidly and after 30 minutes of oxygen deficiency contractile activity ceased. Reintroduction of oxygen after 15 minutes of anoxia resulted in full recovery of contraction strength for both control and glucose deficient muscles. After longer periods of anoxia, aerobic recovery was greater for muscles with glucose present during the anaerobic period. Little aerobic recovery was noted for muscles in glucose deficient medium during the 60 minutes of anoxia.
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Martin M. Winbury (1956) studied this question.
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