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July 13, 1978New England Journal of Medicine

A Randomized Trial of Aspirin and Sulfinpyrazone in Threatened Stroke

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Why the study?

Does aspirin or sulfinpyrazone reduce the occurrence of continuing transient ischemic attacks, stroke or death in patients with threatened stroke?

Population

585 patients with threatened stroke

Design

RCT, randomized

Follow-up

average of 26 months

Discussion

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Implication

Supports aspirin for men with threatened stroke; confirms antiplatelet benefit and extends evidence to cerebrovascular secondary prevention.

Structured PICO

Does aspirin or sulfinpyrazone reduce the occurrence of continuing transient ischemic attacks, stroke or death in patients with threatened stroke?

P
Population
585 patients with threatened stroke
I
Intervention
Aspirin or sulfinpyrazone, singly or in combination
O
Outcome
occurrence of continuing transient ischemic attacks, stroke or deathcomposite

Aspirin significantly reduces the risk of stroke or death in men with threatened stroke, whereas sulfinpyrazone shows no significant benefit.

Cite This Study

A 1978 study studied this question.

synapsesocial.com/papers/6a7f3499290a50e19e6f389chttps://doi.org/10.1056/nejm197807132990201
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Altered Platelet Function in Patients with Prosthetic Mitral Valves Effects of Sulfinpyrazone Therapy1970 · 118 citations
  2. 2Aspirin Prophylaxis of Venous Thromboembolism after Total Hip Replacement1977 · 344 citations
  3. 3Sulfinpyrazone in the Prevention of Cardiac Death after Myocardial Infarction1978 · 299 citations
  4. 4Controlled trial of aspirin in cerebral ischemia.1977 · 632 citations