Key result
Hospitalization for hand, foot, and mouth disease was associated with an improvement in mean health utility score from 0.730 at admission to 0.920 at discharge, alongside a heavy economic burden that varied by region.
Why the study?
Hand, foot, and mouth disease causes high morbidity and mortality among children under 5 years old, prompting investigation into health-related quality of life, economic burden, and associated influencing factors in China.
Cohort (n=296)
Yes
Hospitalized children with HFMD in China experience significantly reduced health-related quality of life at admission that improves by discharge, alongside a substantial economic burden that varies by region.
Answers are grounded in this paper and cite their sources.
May warrant monitoring residual HRQOL issues after pediatric HFMD; leaves open region-tailored support and vaccine economic evaluations.
BACKGROUND: Hand, foot, and mouth disease (HFMD) is an infectious disease with high morbidity and mortality rates among children under 5 years old. This study aimed to explore the health-related quality of life (HRQOL), economic burden, and related influencing factors among Chinese HFMD patients. METHODS: From January to October 2019, a longitudinal cohort study of 296 hospitalized patients (≤ 5 years old) with HFMD and their guardians was conducted using the proxy version of the 5-level EQ-5D-Y (EQ-5D-Y-5L, Y-5L) in face-to-face interviews in Shanghai, Zhengzhou, and Kunming, representing three regions with different economic development levels. Multiple linear regression was used to explore the factors associated with HRQOL and costs. RESULTS: The mean Y-5L health utility score (HUS) (standard deviation, SD), and visual analogue scale (VAS) score (SD) were 0.730 (0.140) and 60.33 (16.52) at admission and increased to 0.920 (0.120) and 89.95 (11.88) at discharge, respectively. The children from Shanghai had the lowest HUSs at admission and had the best health improvement. The mean hospitalization cost and total cost were 4037 CNY and 5157 CNY, respectively. The children from Shanghai had the highest hospitalization cost (4559 CNY) and total cost (5491 CNY). Multiple regression analysis suggested that medical insurance status, type of employment, residence type, and religious status were significantly associated with the baseline HUS and improvement in the HUS after treatment. Region, loss of work time, and length of stay had a significant impact on the hospitalization cost and total cost. CONCLUSION: Our findings demonstrate that HFMD could lead to poor HRQOL and the economic burden varies in different regions in China. Many pediatric patients still have physical or mental health problems shortly after treatment.
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Zhou et al. (2024) conducted a cohort in Hand, foot, and mouth disease (HFMD) (n=296). Hospitalization and treatment for HFMD vs. Baseline (at admission) was evaluated on Y-5L health utility score (HUS) (Mean difference 0.18). Hospitalization for hand, foot, and mouth disease was associated with an improvement in mean health utility score from 0.730 at admission to 0.920 at discharge, alongside a heavy economic burden that varied by region.
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