Key result
Planned percutaneous mitral valve repair with Impella CP assistance was feasible and safe in two high-risk patients, with no procedure-related complications and improved symptoms at 6 months.
Why the study?
Advanced ventricular support during PMVR is typically confined to emergency or bailout situations, with no reported cases of planned use in high-risk patients.
Does planned Impella CP mechanical circulatory support improve safety and outcomes in high-risk patients undergoing percutaneous mitral valve repair?
Case Report (n=2)
Does planned Impella CP mechanical circulatory support improve safety and outcomes in high-risk patients undergoing percutaneous mitral valve repair?
Planned use of Impella CP mechanical circulatory support during percutaneous mitral valve repair in high-risk patients appears feasible and safe, potentially improving clinical outcomes.
BACKGROUND: Currently, the use of advanced ventricular support systems during percutaneous mitral valve repair (PMVR) procedures is confined to very few selected cases in emergency or bailout situations. No cases are reported of planned use of ventricular support devices in the subgroup of high-risk patients undergoing PMVR. CASE SUMMARY: We report two cases of planned and 'protected' procedures of PMVR with Impella CP mechanical circulatory support. No procedure-related complications occurred. At 6-month clinical follow-up evaluation, an improvement of symptoms and functional class (New York Heart Association) was reported. DISCUSSION: In the two cases reported, PMVR with Impella CP assistance was feasible, safe and effective in the setting of severe mitral regurgitation associated with dilated and severe left ventricular dysfunction. Extending the concept of 'complex high-risk and indicated patients/procedures' (CHIP) from the environment of coronary intervention, a 'protected' approach could lead to improve technical feasibility and clinical outcome in structural interventions, as advocated for 'protected-percutaneous coronary intervention'.
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Muraca et al. (2020) conducted a case report in Severe mitral regurgitation with severe left ventricular dysfunction (n=2). Percutaneous mitral valve repair (PMVR) with Impella CP mechanical circulatory support was evaluated on Procedure-related complications and clinical improvement at 6 months. Planned percutaneous mitral valve repair with Impella CP assistance was feasible and safe in two high-risk patients, with no procedure-related complications and improved symptoms at 6 months.
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