Key result
Low dose aspirin (100 mg daily) significantly reduced the incidence of preeclampsia compared to no treatment (16% vs 40%, p<0.001) in low-risk pregnant women with abnormal uterine artery Doppler.
Why the study?
Does low dose aspirin reduce the incidence of preeclampsia in low risk pregnant ladies with abnormal uterine artery Doppler results?
RCT (n=50)
Open-label
Randomized
No
Does low dose aspirin reduce the incidence of preeclampsia in low risk pregnant ladies with abnormal uterine artery Doppler results?
Absolute Event Rate: 16% vs 40%
p-value: p=<0.001
Low dose aspirin administration in early pregnancy significantly reduces the incidence of preeclampsia in low-risk women with abnormal uterine artery Doppler results.
Supports low-dose aspirin prophylaxis in low-risk women with abnormal Doppler; extends evidence beyond high-risk populations.
This study aimed to identify the effect of low dose aspirin administration in low risk pregnant ladies who have abnormal uterine artery Doppler results. Patients and Methods: A randomized clinical trial was performed on 50 pregnant ladies (≥16 weeks of gestation) in Sulaymaniyah Maternity Teaching Hospital during January 2017 to January 2018. The participants were randomly enrolled into two groups; the participants in the first group were given 100 mg of aspirin tablet each but the other group was given nothing. Results: Preeclampsia was significantly (P-value of <0.001) less in the aspirin group as compared to the other group (16% and 40% respectively). The pulsatility index (PI) was not significantly different in both the groups (P-value = 0.69), but resistance index (RI) was significantly lower in the aspirin group (P-value of <0.001). Conclusion: Doppler study of the uterine artery at 16 weeks or higher in low risk pregnant women appears to be useful as a screening test and low dose of aspirin therapy at early stage of pregnancy will decrease the incidence of preeclampsia.
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Ali et al. (2018) conducted an RCT in Abnormal uterine artery Doppler results in low-risk pregnancy (n=50). Aspirin vs. No treatment was evaluated on Preeclampsia (p=<0.001). Low dose aspirin (100 mg daily) significantly reduced the incidence of preeclampsia compared to no treatment (16% vs 40%, p<0.001) in low-risk pregnant women with abnormal uterine artery Doppler.