Key result
Transcatheter tricuspid valve replacement achieved a 94% technical success rate and significantly improved TR severity (OR 0.0013; 95% CI 0.0006-0.0027; p<0.001) with 9% 1-year mortality.
Why the study?
Due to the high risks associated with conventional surgery for tricuspid regurgitation, transcatheter tricuspid valve replacement has emerged as a less invasive alternative requiring systematic evaluation.
Does transcatheter tricuspid valve replacement improve clinical outcomes and echocardiographic indices in patients with moderate to severe tricuspid regurgitation?
Meta-Analysis (n=643)
Does transcatheter tricuspid valve replacement improve clinical outcomes and echocardiographic indices in patients with moderate to severe tricuspid regurgitation?
Odds Ratio: 0.0013 (95% CI 0.0006–0.0027)
p-value: p=<0.001
TTVR is a promising, technically successful, and safe alternative for high-risk patients with severe tricuspid regurgitation, leading to significant echocardiographic improvements.
No takes yet. Share an insight, caveat, or question.
May support TTVR consideration in high-risk inoperable severe TR; leaves open long-term durability and selection pending RCTs.
Azami et al. (2025) conducted a meta-analysis in Moderate to severe tricuspid regurgitation (n=643). Transcatheter tricuspid valve replacement (TTVR) was evaluated on TR severity (OR 0.0013, 95% CI 0.0006-0.0027, p=<0.001). Transcatheter tricuspid valve replacement achieved a 94% technical success rate and significantly improved TR severity (OR 0.0013; 95% CI 0.0006-0.0027; p<0.001) with 9% 1-year mortality.
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