Key result
Paeoniflorin significantly attenuated cardiac remodeling and improved cardiac function in chronic heart failure rats, reducing collagen volume fraction compared to vehicle (13.75% vs 30.97%, P<0.001).
Why the study?
Cardiac remodeling is an important mechanism in CHF, and paeoniflorin has anti-inflammatory properties, but its effects and mechanisms on cardiac remodeling in CHF required assessment.
Does paeoniflorin attenuate cardiac remodeling and improve cardiac function in a rat model of chronic heart failure?
Does paeoniflorin attenuate cardiac remodeling and improve cardiac function in a rat model of chronic heart failure?
Absolute Event Rate: 13.75% vs 30.97%
p-value: p=<0.001
Paeoniflorin attenuates cardiac remodeling and improves cardiac function in a rat model of chronic heart failure, likely by down-regulating the TGF-β1/Smad signaling pathway.
Should not change HF practice; leaves open whether paeoniflorin remodeling benefits translate from rats to humans.
BACKGROUND: Cardiac remodeling is an important mechanism for the occurrence and development of chronic heart failure (CHF). Paeoniflorin (Pae) is the main active ingredient of Chinese herbaceous peony and has novel anti-inflammatory effect. This study was conducted to assess the effects and mechanisms of Pae on cardiac remodeling in CHF rats. METHODS: A cardiac remodeling rat model was induced by isoprenaline (Iso). Pae (20 µg/kg/d) was administrated to CHF rats for six weeks. Cardiac ultrasound was used to assess the structure and function of CHF rats. Collagen volume fraction (CVF) and perivascular collagen volume area of myocardial tissues were calculated. With real-time polymerase chain reaction and Western blot, the protein and mRNA levels of transforming growth factor β1 (TGF-β1) and Smad3 were detected. RESULTS: Compared to Iso group, Pae can alleviate cardiac remodeling and improve cardiac function in CHF rats. The levels of CVF and perivascular collagen volume area reduced in Pae group (P<0.05). The expression of TGF-β1 and Smad3 protein decreased in Pae and Cap group (P<0.05). Further, the expression of TGF-β1 and Smad3 mRNA also decreased markedly in the Pae group (P<0.05). CONCLUSIONS: Pae could attenuate cardiac remodeling and improve cardiac function in CHF rats. The potential mechanism for the cardioprotective effect of Pae may be highly associated with the down-regulating of TGF-β1/Smad signaling pathway.
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Liu et al. (2019) studied Chronic heart failure (n=32). Paeoniflorin vs. Isoprenaline (Iso) vehicle control was evaluated on Collagen volume fraction (CVF) (p=<0.001). Paeoniflorin significantly attenuated cardiac remodeling and improved cardiac function in chronic heart failure rats, reducing collagen volume fraction compared to vehicle (13.75% vs 30.97%, P<0.001).
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