What question did this study set out to answer?

To evaluate the incidence of cutaneous carcinoma in patients receiving oral 8-methoxypsoralen photochemotherapy for psoriasis.

April 12, 1979New England Journal of Medicine

Risk of Cutaneous Carcinoma in Patients Treated with Oral Methoxsalen Photochemotherapy for Psoriasis

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Authors

RSRobert S. SternBeth Israel Deaconess Medical Center LTL. A. ThibodeauEducational Testing Service RKRuth A. KleinermanNational Cancer Institute

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Implication

Prospective study reveals increased cutaneous carcinoma risk in psoriasis patients given oral methoxsalen photochemotherapy, highlighting greater vulnerability with prior radiation exposure.

Key Points

To evaluate the incidence of cutaneous carcinoma in patients receiving oral 8-methoxypsoralen photochemotherapy for psoriasis.
Conducted a 2.1-year prospective study in 1,373 patients receiving oral 8-methoxypsoralen photochemotherapy for psoriasis.
Tracked the incidence of basal-cell and squamous-cell carcinomas compared with expected rates from an age-, sex-, and geographically matched population.
Cutaneous carcinoma developed in 30 patients (48 total carcinomas), representing an observed incidence 2.63 times expected (95% CI, 1.91 to 3.90).
Relative risk of carcinoma was 3.68 (99% CI, 2.42 to 8.69) for patients with prior ionizing radiation and 10.22 (99% CI, 4.78 to 37.08) for those with prior cutaneous carcinoma.
Patients demonstrated a higher than expected proportion of squamous-cell carcinomas, with an excess occurring in non-sun-exposed areas.

Cite This Study

Stern et al. (1979) studied this question.

synapsesocial.com/papers/6a7f3afce9877cc9856a7f7b https://doi.org/10.1056/nejm197904123001501

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Implication

Prospective study reveals increased cutaneous carcinoma risk in psoriasis patients given oral methoxsalen photochemotherapy, highlighting greater vulnerability with prior radiation exposure.

Risk of Cutaneous Carcinoma in Patients Treated with Oral Methoxsalen Photochemotherapy for Psoriasis

Discussion

Member takes

Implication

Key Points

Cite This Study

Risk of Cutaneous Carcinoma in Patients Treated with Oral Methoxsalen Photochemotherapy for Psoriasis

Discussion

Member takes

Implication

Key Points

Cite This Study

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