Population
Rabbit skeletal muscle alpha-tropomyosin (Tm) and deletion mutant (D234Tm) reconstituted thin filaments
Comparison
Addition of Ca2+ and myosin subfragment 1 (S1) vs Absence of Ca2+ and S1
Design
Preclinical
Authors
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Structural evidence for three thin-filament states in skeletal muscle; leaves open relevance to human cardiac regulation or therapy.
FRET measurements provide structural evidence for three states of thin filaments (relaxed, Ca2+-induced or closed, and S1-induced or open states) in the regulation of skeletal muscle contraction.
Hai et al. (2002) studied this question.
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