Why the study?
Does H2S induce vasorelaxation via KCNQ-type Kv channels and does CSE-derived H2S mediate the anticontractile effects of perivascular adipose tissue in rat and mouse aortas?
Does H2S induce vasorelaxation via KCNQ-type Kv channels and does CSE-derived H2S mediate the anticontractile effects of perivascular adipose tissue in rat and mouse aortas?
H2S donors induce potent vasorelaxation in rat and mouse aortas via KCNQ-type potassium channels, with CSE-derived H2S modulating perivascular adipose tissue effects in rats but not mice.
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Does not support clinical translation of H2S donors; leaves open KCNQ and species-specific PVAT mechanisms for further rodent-to-human studies.
Köhn et al. (2012) studied this question.
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