Population
Adult rat cardiac myocytes cultured on a flexible silicone rubber substratum
Design
Preclinical
Follow-up
8 or more days in culture
Authors
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No immediate clinical implications; leaves open costamere force transmission in intact adult or human myocardium.
Costameres mechanically link myofibrils to the extracellular matrix in adult rat cardiomyocytes, transmitting contractile forces to the substratum.
Danowski et al. (1992) studied this question.
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