What question did this study set out to answer?

To establish standardized pan-European data regarding the frequency, eliciting factors, clinical manifestations, and medical management of severe allergic reactions referred to specialist centers.

August 16, 2014AllergyOpen Access

First European data from the network of severe allergic reactions (NORA)

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Authors

MWMargitta WormBoston Children's Hospital AMAnne Moneret-VautrinUniversité de Lille KSKathrin SchererKantonsspital Aarau

Discussion

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Implication

Registry study reveals food and insect venom as leading anaphylaxis triggers across European patients, indicating significant underuse of first-line adrenaline.

Key Points

To establish standardized pan-European data regarding the frequency, eliciting factors, clinical manifestations, and medical management of severe allergic reactions referred to specialist centers.
Conducted a pilot multicenter registry study across 59 tertiary allergy, dermatology, and pediatric units in 10 European countries between June 2011 and March 2014.
Collected standardized diagnostic and medical history data via an online questionnaire for N=3333 confirmed cases of anaphylaxis.
Food was the leading elicitor in pediatric patients (64.9% vs. 20.2% in adults), while insect venom was the primary trigger in adults (48.2% vs. 20.2% in children); drugs triggered 22.4% of adult and 4.8% of pediatric reactions.
Most reactions developed within 30 minutes of exposure (80.5%), with the skin affected in 84.1% of cases, and 34.2% of patients reported a prior milder reaction to the culprit allergen.
Professional first-line intervention heavily utilized corticoids (60.4%) and antihistamines (52.8%), whereas on-site self- or lay-administered adrenaline occurred in only 13.7% of food-induced and 27.6% of venom-induced anaphylaxis cases.

Cite This Study

Worm et al. (2014) studied this question.

synapsesocial.com/papers/6a7f4021b4cedf233c7ca296 https://doi.org/10.1111/all.12475

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Implication

Registry study reveals food and insect venom as leading anaphylaxis triggers across European patients, indicating significant underuse of first-line adrenaline.

First European data from the network of severe allergic reactions (NORA)

Discussion

Member takes

Implication

Key Points

Cite This Study

First European data from the network of severe allergic reactions (NORA)

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider