Key result
While left atrial appendage removal is established for rheumatic mitral valve disease with atrial fibrillation, further randomized studies are needed to determine if it should be removed in all cases.
Why the study?
Should the left atrial appendage be removed in all cases of mitral valve surgery?
Further randomized studies are needed to determine if left atrial appendage removal should be routinely performed during mitral valve surgery, particularly in patients with normal sinus rhythm.
Atrial fibrillation is the most common arrhythmia in worldwide. The left atrial appendage morphology with long body and narrow base, blood stasis and atrial fibrillation increase thrombi formation. Cardioembolic strokes are 17.9-fold more frequent in non-valvular atrial fibrillation patients than those without atrial fibrillation. The efficacy of chronic anticoagulation therapy to prevent ischemic strokes in atrial fibrillation is well established. Adjusted-dose warfarin reduces stroke by 60% and death by 25% compared with no antithrombotic treatment. Introduction of NOACs agents has help to increase the proportion of atrial fibrillation patients receiving anticoagulant therapy. However, despite demonstrated efficacy and professional guideline recommendations, oral anticoagulation treatment rates in patients with atrial fibrillation are generally below 60%. Left atrial appendage occlussion has now become the most preferred method of choice for reducing the possibility of stroke in non-valvular atrial fibrillation, especially in cases in which oral anticoagulant therapy is contraindicated. It is well established the usefulness of the left atrial appendage removal in patients with rheumatic mitral valve disease and atrial fibrillation. Theoretically, removal of the left atrial appendage in patients with mitral valve disease in normal sinus rhythm could have several advantages, taking into account that 26% of mitral valve operations exhibits postoperative atrial fibrillation. Nevertheless, further randomized studies are needed to answer if LAA should be removed in all cases of MV surgery.
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A 2017 study conducted a review in Atrial fibrillation and mitral valve disease. Left atrial appendage removal was evaluated. While left atrial appendage removal is established for rheumatic mitral valve disease with atrial fibrillation, further randomized studies are needed to determine if it should be removed in all cases.
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