Why the study?
Does recombinant human brain natriuretic peptide (rhBNP) ameliorate trauma-induced acute lung injury in rats?
Population
Sprague-Dawley rats with trauma-induced acute lung injury (ALI)
Comparison
Recombinant human brain natriuretic peptide… vs ALI group, sham-operated group, control group…
Design
Preclinical, randomly divided
Follow-up
Up to 7 days
Authors
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Rat model data are hypothesis-generating; leaves open any role for rhBNP in human trauma-induced ALI.
Does recombinant human brain natriuretic peptide (rhBNP) ameliorate trauma-induced acute lung injury in rats?
rhBNP protects against trauma-induced acute lung injury in rats, likely by inhibiting the JAK/STAT signaling pathway.
Song et al. (2015) studied this question.
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