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June 6, 2013ViewOpen Access

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

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Population

270,775 individuals of European and European American descent across 94 studies.

Design

Meta-analysis

Authors

JRJoshua C. RandallWellcome Sanger InstituteTWThomas W. WinklerUniversity of North Carolina at Chapel Hill
Zoltán Kutalik
Zoltán KutalikSIB Swiss Institute of Bioinformatics

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Overview

Does not yet inform clinical risk models; extends GWAS meta-analyses by confirming female-predominant loci for waist phenotypes.

Structured PICO

P
Population
270,775 individuals of European and European American descent across 94 studies (133,723 in discovery meta-analysis, 137,052 in follow-up).
O
Outcome
Sexually dimorphic genetic associations with anthropometric traits (height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio)surrogate

This large-scale GWAS meta-analysis demonstrates significant sexual dimorphism in genetic loci associated with waist phenotypes, with effects predominantly observed in women.

Cite This Study

Randall et al. (2013) studied this question.

synapsesocial.com/papers/6a7f47a3e8cd0f703b896353https://doi.org/10.1371/journal.pgen.1003500
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