What question did this study set out to answer?

To develop an ultrasound-responsive piezoelectric nanoreactor that eradicates drug-resistant bacteria on implants via tandem catalytic reactions and iron metabolism disruption.

March 14, 2025Science AdvancesOpen Access

A multimodal defect-rich nanoreactor triggers sono-piezoelectric tandem catalysis and iron metabolism disruption for implant infections

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Authors

XWXufeng WanSichuan University YZYangming ZhangNantong University YYYan YueQilu University of Technology

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Implication

Preclinical study demonstrates bacterial clearance and enhanced osteogenesis on titanium scaffolds, highlighting a dual-action strategy for treating implant infections.

Key Points

To develop an ultrasound-responsive piezoelectric nanoreactor that eradicates drug-resistant bacteria on implants via tandem catalytic reactions and iron metabolism disruption.
Synthesized an oxygen vacancy–rich (BiFe)0.9(BaTi)0.1O3−x nanoreactor and engineered it onto porous titanium scaffolds.
Applied ultrasound to initiate piezoelectric charge transfer and drive coupled sono- and chemodynamic catalytic reactions.
Performed transcriptomics analysis to evaluate the molecular pathways of bacterial iron overload and ferroptosis-like cell death.
Piezoelectric charges generated hydrogen peroxide while electron-rich oxygen vacancies accelerated Fe(III)/Fe(II) cycling, producing sustained hydroxyl radicals that caused bacterial membrane damage.
Transcriptomics confirmed that intracellular Fe(II) overload dysregulated the bacterial two-component regulatory system and disrupted metabolism, triggering ferroptosis-like death.
Nanoreactor-coated porous titanium scaffolds demonstrated robust antibacterial efficacy under ultrasound activation while facilitating osteogenesis through immunomodulatory mechanisms.

Cite This Study

Wan et al. (2025) studied this question.

synapsesocial.com/papers/6a7f4f178b768b9c059d2f09 https://doi.org/10.1126/sciadv.ads8694

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Implication

Preclinical study demonstrates bacterial clearance and enhanced osteogenesis on titanium scaffolds, highlighting a dual-action strategy for treating implant infections.

A multimodal defect-rich nanoreactor triggers sono-piezoelectric tandem catalysis and iron metabolism disruption for implant infections

Discussion

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Implication

Key Points

Cite This Study

A multimodal defect-rich nanoreactor triggers sono-piezoelectric tandem catalysis and iron metabolism disruption for implant infections

Discussion

Member takes

Implication

Key Points

Cite This Study

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