Why the study?
Despite the prevalence of COPD in the general populace, its occurrence in patients with heart failure was understudied.
In Chinese patients with heart failure, COPD is prevalent (11.6%) and is independently associated with older age, male sex, higher comorbidity burden, elevated PaCO2, and right heart failure.
May warrant COPD screening consideration in older Chinese HF patients; leaves open causal roles and intervention value.
Background Despite chronic obstructive pulmonary disease’s (COPD)'s prevalence in the general populace, its incidence in heart failure (HF) patients is understudied. This study aimed to assess COPD prevalence and clinical associations in Chinese HF patients. Methods From the Chinese Heart Failure Study, demographic and clinical details of 2008 HF patients were analyzed. Divided into 233 COPD cases and 1775 non-COPD controls, a multivariable logistic regression identified factors linked to COPD onset in HF, with thorough examination of intergroup clinical differences. Results The incidence of COPD in HF individuals was 11.60% (233/2008). The COPD subgroup featured a higher ratio of individuals over 60 and males, alongside lower systolic blood pressure (SBP), body mass index (BMI), higher Charlson Comorbidity Index (CCI) scores, and increased PaCO₂ levels ( p < 0.05). Type II respiratory failure and right ventricular dysfunction (RVD) were more prevalent in the COPD subgroup ( p < 0.001). Binary logistic regression, after adjustments, indicated positive associations between COPD and age over 60 (OR = 3.831, 95%CI: 1.085–13.526, p = 0.037), male sex (OR = 1.587, 95%CI: 1.032–2.441, p = 0.036), higher CCI (OR = 2.214, 95%CI: 1.796–2.729, p < 0.001), elevated PaCO 2 (OR = 1.035, 95%CI: 1.015–1.055, p < 0.001), and RVD (OR = 0.605, 95%CI: 0.119–3.063, p = 0.544). Inversely, higher SBP (OR = 0.990, 95%CI: 0.982–0.998, p = 0.020) and log (triglycerides) (OR = 0.183, 95%CI: 0.064–0.552, p = 0.002) were negatively correlated with COPD in HF patients. Conclusion In a large cohort of Chinese Heart Failure (HF) patients, our study revealed a notable COPD prevalence. Key risk factors included age, sex, elevated PaCO 2 , CCI score, and right heart failure, while higher SBP and triglyceride levels offered protection. These insights lay groundwork for probing disease mechanisms and therapeutic approaches.
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Zhu et al. (2025) studied this question.
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