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January 10, 2008Journal of Biological ChemistryOpen Access

Structural Insights into Mechanisms of Catalysis and Inhibition in Norwalk Virus Polymerase

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Population

Norwalk virus polymerase bound to an RNA primer-template duplex

Design

Preclinical

Authors

DZD.F. ZamyatkinUniversity of CalgaryFPFrancisco ParraUniversidad de OviedoJMJosé M. Martín‐AlonsoUniversidad de Oviedo

Discussion

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Overview

No clinical implications from this preclinical structure; leaves open a template for norovirus antiviral design.

Structured PICO

P
Population
Norwalk virus polymerase bound to an RNA primer-template duplex
I
Intervention
Natural substrate CTP or the inhibitor 5-nitrocytidine triphosphate
O
Outcome
Crystal structures determined to 1.8A resolutionsurrogate

The structural insights into the closed conformation of Norwalk virus polymerase bound to an inhibitor suggest a novel approach for designing antiviral compounds.

Cite This Study

Zamyatkin et al. (2008) studied this question.

synapsesocial.com/papers/6a7f4f64aa1ae1567cb3d792https://doi.org/10.1074/jbc.m709563200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Poliovirus RNA-Dependent RNA Polymerase (3D<sup>pol</sup>):  Kinetic, Thermodynamic, and Structural Analysis of Ribonucleotide Selection2004 · 74 citations
  2. 2Poliovirus RNA-Dependent RNA Polymerase (3D<sup>p</sup><sup>ol</sup>):  Pre-Steady-State Kinetic Analysis of Ribonucleotide Incorporation in the Presence of Mg<sup>2+</sup>2004 · 183 citations
  3. 3Poliovirus RNA-dependent RNA Polymerase (3Dpol)2000 · 114 citations
  4. 4Refinement of Macromolecular Structures by the Maximum-Likelihood Method1997 · 14,991 citations
  5. 5Crystal Structure of Norwalk Virus Polymerase Reveals the Carboxyl Terminus in the Active Site Cleft2004 · 123 citations