Population
Poliovirus RNA-dependent RNA polymerase (3Dpol) model
Design
Preclinical
Authors
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Remote RdRp fidelity control may enable allosteric antivirals; leaves open translation beyond poliovirus models.
A remote site from the catalytic center can control the fidelity checkpoint in viral RNA-dependent RNA polymerase, offering a potential target for antiviral drug development.
Arnold et al. (2005) studied this question.
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