Population
Mouse models
Comparison
Ketotic nutritional states vs Chow-fed controls
Design
Preclinical
Authors
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Ketogenic diets may downregulate cardiac ketone oxidation; leaves open effects on myocardial energetics or outcomes in patients.
Ketotic nutrient environments engage mechanisms that curtail ketolytic capacity in the heart, limiting ketone body utilization and failing to inhibit fatty acid oxidation.
Wentz et al. (2010) studied this question.
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