Specialized Management of Oral Anticoagulation Therapy Improves Outcome in Patients with Chronic Renal Insufficiency

Figures

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  Figure 1. Adjusted safety endpoints and outcome measures comparing severe renal failure patients and controls in usual medical care, Cox regression. Forest plot showing the rate ratios and 95% confidence intervals of endpoints; primary long-term outcome: composite endpoint of clinically-relevant non-major and major bleeding, myocardial infarction, systemic and pulmonary embolism, stroke, and death. Adjusted for age, sex, diabetes, dyslipidemia, hypertension, obesity, family history of myocardial infarction, smoking, atrial fibrillation, congestive heart failure, coronary artery disease, previous myocardial infarction, deep vein thrombosis, pulmonary embolism, and liver disease.

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  Figure 2. The adjusted safety endpoints and outcome measures comparing severe renal failure patients in a coagulation service with those receiving usual medical care, Cox regression. Forest plot showing the rate ratios and 95% confidence intervals of endpoints; primary long-term outcome: composite endpoint of clinically relevant non-major and major bleeding, myocardial infarction, systemic and pulmonary embolism, stroke, and death. Adjusted for age, sex, and cardiovascular risk factors.

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  Figure 3. The propensity score adjusted (weighted by inverse probability weights) cumulative incidence plots of the safety endpoints and outcome measures comparing severe renal failure patients and controls in standard care and a coagulation service. (A): long-term outcome, (B): death, (C): hospitalizations, (D): all clinically relevant bleeding, (E): major bleeding, (F): thromboembolic events; Ctrls. Usual care: patients without severe renal failure (RF) managed in usual care; Severe renal failure usual care: patients with severe renal failure managed in usual care; Ctrls. coag. serv.: patients without severe renal failure managed in a coagulation service; severe RF coag. serv.: patients with severe renal failure managed in a coagulation service.