Why the study?
Non-HDL-C is associated with multiple diseases and easy to measure, but its relationship with depression remains unclear.
Are higher non-HDL-C levels associated with an increased risk of depression in adults?
Are higher non-HDL-C levels associated with an increased risk of depression in adults?
Elevated non-HDL-C levels are independently associated with an increased risk of depression in US adults, particularly in men and those without hypertension.
Should not yet change lipid or depression practice; leaves open whether non-HDL-C is a causal or modifiable mood-risk marker.
Objectives: Non-high-density lipoprotein cholesterol (non-HDL-C) has attracted attention because it is associated with a variety of diseases and is easy to measure. However, the relationship between non-HDL-C and depression is still unclear. Our aim was to assess the relationship between non-HDL-C and depression using the cross-sectional NHANES survey from 2005 to 2018. Methods: We examined the association between non-HDL-C and depression using weighted multivariable logistic regression models and subgroup analysis. Sensitivity analysis demonstrated the robustness of the results. Results: < 0.01). There was a positive association between non-HDL-C and depression with a 95% OR of 1.22 adjusted for multifactorial (95% CI,1.03-1.45). In subgroup analyses, non-HDL-C was positively associated with depression in men (OR, 1.31; 95% CI, 1.01-1.70), normal BMI (OR: 0.93; 95% CI: 0.66-1.32) and in participants without hypertension (OR, 1.29; 95% CI, 1.01-1.66). Conclusion: Non-HDL-C positively correlated with depression, and further research may be better for clinical service.
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Zhu et al. (2023) studied this question.
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