Population
Cultured Chinese hamster ovary (CHO) cells (three copper-resistant variants and parental cells)
Comparison
Growth in copper-supplemented media vs Parental CHO cells
Design
Preclinical
Authors
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Cell model data support MNK efflux role; leaves open human disease relevance and requires in vivo validation.
The study provides strong evidence that the MNK protein mediates transmembrane copper efflux and demonstrates a novel system of gene amplification in mammalian cells.
Camakaris et al. (1995) studied this question.
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