Why the study?
Major depressive disorder often coexists with hypertension, and DNA methylation of angiotensin-converting enzyme may play a role in their development.
Does serum ACE methylation level correlate with the presence and severity of comorbid major depressive disorder and hypertension?
Does serum ACE methylation level correlate with the presence and severity of comorbid major depressive disorder and hypertension?
Elevated serum ACE methylation levels are associated with comorbid major depressive disorder and hypertension, and may serve as an independent risk factor for severe depression in these patients.
Answers are grounded in this paper and cite their sources.
Should not yet change diagnostic or risk-stratification practice; leaves open ACE methylation as a biomarker for comorbid MDD-hypertension.
OBJECTIVE: Major depressive disorder (MDD) often coexists with hypertension (HYT). DNA methylation has elicited vital functionality in their development. Angiotensin-converting enzyme (ACE) is a vital enzyme in blood pressure. This study investigated the effect of ACE methylation on depression and HYT severity in patients with comorbid MDD and HYT (MDD + HYT). METHODS: A total of 119 patients (41 men, 78 women, average age: 56.8 ± 9.1 years) with MDD + HYT were enrolled, with 89 healthy subjects (29 men, 60 women, average age: 57.4 ± 9.7 years) were enrolled. The Hamilton Depression Rating Scale-17 and self-rating depression scale scoring scales were used to assess the depression degree of patients, serum ACE methylation level in MDD + HYT patients was measured by means of bisulfite sequencing polymerase chain reaction, with subsequent analysis of the diagnostic efficacy of ACE methylation for MDD + HYT. The independent risk factors for sMDD + HYT were explored. RESULTS: Serum ACE methylation levels were significantly increased in MDD + HYT patients. The area under the curve of serum ACE methylation level for accurate diagnosis of MDD + HYT was 0.8471, and the cut-off value was 26.9 (sensitivity 83.19%, specificity 73.03%). ACE methylation was an independent risk factor for sMDD + HYT (P = 0.014; odds ratio, 1.071; 95% confidence interval = 1.014-1.131). CONCLUSION: The elevated serum ACE methylation level (P < 0.001) in patients with MDD + HYT elicited definite diagnostic values for MDD + HYT, and ACE methylation level was independently correlated with sMDD + HYT (P < 0.05).
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Abula et al. (2023) studied this question.
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