May 24, 2019Scientific ReportsOpen Access

Association between depressive-symptom trajectories and cognitive function in the late middle-aged and older population: results of the Korean Longitudinal Study of Ageing

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Why the study?

This study investigated the association between depressive symptoms and cognitive function across four trajectories of depressive symptoms in late middle-aged and older individuals.

Population

4,374 late middle-aged and older South Korean participants

Comparison

Increasing, moderate declining, and high vs low depressive-symptom trajectories

Design

Panel data longitudinal study

Authors

DCDong‐Woo ChoiNational Cancer Center KHKyu‐Tae HanNational Cancer Center JJJooeun JeonGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Depressive trajectories flag higher cognitive risk in older adults; hypothesis-generating for whether mood interventions slow decline.

Structured PICO

Population

4,374 late middle-aged and older adults (aged ≥45 years) from the Korean Longitudinal Study of Ageing (KLoSA), excluding individuals with suspected dementia (MMSE < 17 at baseline) or missing covariate data.

Intervention

Increasing, moderate declining, and high depressive-symptom trajectories (assessed via CES-D10)

Comparator

Low depressive-symptom trajectory

Outcome

Cognitive function measured by the Mini-Mental State Examination (MMSE) scoresurrogate

Increasing, moderate declining, and high depressive-symptom trajectories are associated with greater cognitive decline in late middle-aged and older adults compared to a low depressive-symptom trajectory.

Limitations

Subjective or erroneous participant scores for CES-D10 and MMSE
Uncertainty of class membership not fully considered in trajectory model
Health behaviors not assessed with specific scales
Sex differences not fully assessed
Potential cohort effects due to broad age range
Potential unmeasured confounding

Cite This Study

Choi et al. (2019) studied this question.

synapsesocial.com/papers/6a7f613887803c5a2dba766c https://doi.org/10.1038/s41598-019-44158-7

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Association between depressive-symptom trajectories and cognitive function in the late middle-aged and older population: results of the Korean Longitudinal Study of Ageing

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Association between depressive-symptom trajectories and cognitive function in the late middle-aged and older population: results of the Korean Longitudinal Study of Ageing

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider