Visualization of painful inflammation in patients with pain after traumatic ankle sprain using [ ¹¹ C]-D-deprenyl PET/CT

BACKGROUND AND AIMS: C]-D-deprenyl uptake would be acutely elevated in unilateral ankle sprain and if tracer uptake would be reduced as a function of healing, and correlated with pain localizations and pain experience. METHODS: C]-D-deprenyl PET/CT in the acute phase, at one month and 6-14 months after injury. RESULTS: C]-D-deprenyl uptake in painful locations. CONCLUSIONS AND IMPLICATIONS: C]-D-deprenyl PET can visualize, quantify and follow processes in peripheral tissue that may relate to soft tissue injuries, inflammation and associated nociceptive signaling. Such an objective correlate would represent a progress in pain research, as well as in clinical pain diagnostics and management.