November 29, 2024British Journal of Clinical Pharmacology

The editorial emphasizes the need for a patient-centered, pragmatic framework for managing heart failure therapies in complex older adults, highlighting recent evidence that tapering RAAS inhibitors in CKD and discontinuing beta-blockers in HFpEF may be feasible.

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Why the study?

Older adults with heart failure have high event rates but are complex and underrepresented in landmark trials, leaving unclear the net benefit of guideline-directed medical therapies and optimal deprescribing strategies.

Design

Editorial

Authors

LLLorenz Van der Linden RTRoss T. Tsuyuki

Discussion

Member takes

Overview

Supports deprescribing trials in frail older HF patients; leaves open confirmation before changing practice.

Structured PICO

Population

Complex older adults with heart failure, particularly those with multimorbidity and frailty

Intervention

Guideline-directed medical therapy (initiation, uptitration, or deprescribing)

Managing heart failure in complex, frail older adults requires a tailored, patient-centered approach to balance the benefits of guideline-directed medical therapy against the risks of polypharmacy and adverse drug reactions.

Cite This Study

Linden et al. (2024) studied this question.

synapsesocial.com/papers/6a7f6853dc397acca2f209f3 https://doi.org/10.1111/bcp.16357

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November 29, 2024British Journal of Clinical Pharmacology

The editorial emphasizes the need for a patient-centered, pragmatic framework for managing heart failure therapies in complex older adults, highlighting recent evidence that tapering RAAS inhibitors in CKD and discontinuing beta-blockers in HFpEF may be feasible.

View Full Paper

Ask AI

Bookmark

Why the study?

Design

Editorial

Authors

LLLorenz Van der Linden RTRoss T. Tsuyuki

Discussion

Member takes

Overview

Supports deprescribing trials in frail older HF patients; leaves open confirmation before changing practice.

Structured PICO

Population

Complex older adults with heart failure, particularly those with multimorbidity and frailty

Intervention

Guideline-directed medical therapy (initiation, uptitration, or deprescribing)

Cite This Study

Linden et al. (2024) studied this question.

synapsesocial.com/papers/6a7f6853dc397acca2f209f3 https://doi.org/10.1111/bcp.16357

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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