January 1, 1981AJP Gastrointestinal and Liver Physiology
Response of rat jejunum to angiotensin II: role of norepinephrine and prostaglandins
Population
Pentobarbital sodium-anesthetized rats
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Animal findings on biphasic AII effects should not guide clinical fluid management; leaves open dose-dependent intestinal transport mechanisms for human study.
Structured PICO
P
Population
Pentobarbital sodium-anesthetized rats
I
Intervention
Angiotensin II (AII) at low and high doses, and AII analogue [Sar1,Leu8]AII, with or without cycloheximide, meclofenamate, or indomethacin
O
Outcome
Jejunal sodium and water absorptionsurrogate
Angiotensin II has dose-dependent, biphasic effects on rat jejunal water and sodium absorption, mediated by different pathways including prostaglandin biosynthesis at high doses.
Cite This Study
Levens et al. (1981) studied this question.